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The Platt Lab | The Addi and Cassi Fund - Niemann Pick Type C

Sunday, September 19, 2021

Sphingosine and Calcium Defect Causes Niemann Pick Type C, Cholesterol Downstream Effect Of The Disease

October 28, 2008 by  
Filed under NPC News

In a recent issue of Nature Medicine, Oxford University reports that Niemann Pick Type C disease is a sphingosine storage disease that causes deregulation of lysosomal calcium.  According to Oxford researchers, there is a block in the late endosome to lysosome transport in NPC disease, resulting in the downstream storage of cholesterol and glycosphingolipids (a […]