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	<title>The Addi and Cassi Fund - Niemann Pick Type C &#187; Hydroxy Propel Beta Cyclodextrin</title>
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	<description>Treatments &#38; Cures for Niemann Pick Type C - Childhood Alzheimer&#039;s</description>
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		<title>Cyclodextrins &#8211; Recipes To Make Edible Nanostructures and CD MOFs To LifeSaving Drug Treatments</title>
		<link>http://addiandcassi.com/cyclodextrins-recipes-edible-nanostructures-cd-mofs-lifesaving-drug-treatments/</link>
		<comments>http://addiandcassi.com/cyclodextrins-recipes-edible-nanostructures-cd-mofs-lifesaving-drug-treatments/#comments</comments>
		<pubDate>Tue, 07 Sep 2010 01:11:20 +0000</pubDate>
		<dc:creator>Chris Hempel</dc:creator>
				<category><![CDATA[Cyclodextrin]]></category>
		<category><![CDATA[7 ketocholesterol]]></category>
		<category><![CDATA[Angewandte Chemie]]></category>
		<category><![CDATA[blood brain barrier]]></category>
		<category><![CDATA[CD MOF]]></category>
		<category><![CDATA[Cholesterol]]></category>
		<category><![CDATA[cyclodextrin MOF]]></category>
		<category><![CDATA[edible nanostructures]]></category>
		<category><![CDATA[gamma cycloextrin]]></category>
		<category><![CDATA[gelastic cataplexy]]></category>
		<category><![CDATA[HPBCD]]></category>
		<category><![CDATA[Hydroxy Propel Beta Cyclodextrin]]></category>
		<category><![CDATA[J. Fraser Stoddart]]></category>
		<category><![CDATA[Jeremiah Gassensmith]]></category>
		<category><![CDATA[Kenneth Chang]]></category>
		<category><![CDATA[metal-organic frameworks]]></category>
		<category><![CDATA[nanoparticles]]></category>
		<category><![CDATA[New York Times]]></category>
		<category><![CDATA[Niemann Pick Type C]]></category>
		<category><![CDATA[Ronald Smaldone]]></category>
		<category><![CDATA[Trappsol]]></category>
		<category><![CDATA[United States Food and Drug Administration]]></category>
		<category><![CDATA[Wylie Dufresne]]></category>

		<guid isPermaLink="false">http://addiandcassi.com/?p=3102</guid>
		<description><![CDATA[Kenneth Chang of the New York Times reports on researchers creating edible nanostructures with gamma cyclodextrin which researchers are calling edible CD MOF (metal-organic frameworks). Of course, another amazing discovery with cyclodextrin that was found by accident! Potential applications with this gamma cyclodextrin (CD MOF) could include storing hydrogen in future fuel cells in cars. [...]]]></description>
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		<slash:comments>0</slash:comments>
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		<title>IND Application Filed With FDA To Bring Cyclodextrin Into The Brain To Treat Fatal Childhood Cholesterol Disease</title>
		<link>http://addiandcassi.com/ind-filings-intratehcal-cyclodextrin-treatment-fda/</link>
		<comments>http://addiandcassi.com/ind-filings-intratehcal-cyclodextrin-treatment-fda/#comments</comments>
		<pubDate>Sat, 17 Jul 2010 17:03:08 +0000</pubDate>
		<dc:creator>Chris Hempel</dc:creator>
				<category><![CDATA[Cyclodextrin]]></category>
		<category><![CDATA[Childhood Alzheimers]]></category>
		<category><![CDATA[Children's Hospital & Research Center Oakland]]></category>
		<category><![CDATA[CYCLO]]></category>
		<category><![CDATA[dementia treatment]]></category>
		<category><![CDATA[Dr. John Dietschy]]></category>
		<category><![CDATA[FDA]]></category>
		<category><![CDATA[Hydroxy Propel Beta Cyclodextrin]]></category>
		<category><![CDATA[intrathecal cyclodextrin]]></category>
		<category><![CDATA[Investigational New Drug Application]]></category>
		<category><![CDATA[New Cholesterol Drug]]></category>
		<category><![CDATA[Niemann Pick Type C]]></category>
		<category><![CDATA[NINDS]]></category>
		<category><![CDATA[rare disease]]></category>
		<category><![CDATA[UT Southwestern]]></category>

		<guid isPermaLink="false">http://addiandcassi.com/?p=2873</guid>
		<description><![CDATA[After months and months of work and input by doctors and researchers, Dr. Caroline Hastings at Children&#8217;s Hospital Research Center Oakland filed our second Investigational New Drug application (IND) with the FDA on July 14, 2010. The 200+ page IND filing details our request to deliver hydroxy-propel-beta-cyclodextrin (HPBCD or CYCLO) directly into Addi and Cassi&#8217;s [...]]]></description>
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		<slash:comments>4</slash:comments>
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		<item>
		<title>FDA Grants Orphan Drug Status For Cyclodextrin Compound To Treat Fatal Genetic Cholesterol Disease</title>
		<link>http://addiandcassi.com/fda-grants-orphan-drug-status-for-cyclodextrin-compound-to-treat-fatal-genetic-cholesterol-disease/</link>
		<comments>http://addiandcassi.com/fda-grants-orphan-drug-status-for-cyclodextrin-compound-to-treat-fatal-genetic-cholesterol-disease/#comments</comments>
		<pubDate>Sun, 16 May 2010 19:16:12 +0000</pubDate>
		<dc:creator>Chris Hempel</dc:creator>
				<category><![CDATA[Featured Stories]]></category>
		<category><![CDATA[Actelion]]></category>
		<category><![CDATA[Children's Hospital Oakland and Research Center]]></category>
		<category><![CDATA[Cholesterol]]></category>
		<category><![CDATA[CTD Holdings]]></category>
		<category><![CDATA[Cyclodextrin]]></category>
		<category><![CDATA[Dementia]]></category>
		<category><![CDATA[EMA]]></category>
		<category><![CDATA[FDA]]></category>
		<category><![CDATA[FDA Annual Report]]></category>
		<category><![CDATA[human cholesterol metabolism]]></category>
		<category><![CDATA[Hydroxy Propel Beta Cyclodextrin]]></category>
		<category><![CDATA[Niemann Pick Type C]]></category>
		<category><![CDATA[Orphan Drug Application]]></category>
		<category><![CDATA[Orphan Drug Designation]]></category>
		<category><![CDATA[rare disease]]></category>
		<category><![CDATA[Trappsol]]></category>
		<category><![CDATA[U.S. Food and Drug Administration]]></category>
		<category><![CDATA[Ultra rare diseases]]></category>
		<category><![CDATA[Zavesca]]></category>

		<guid isPermaLink="false">http://addiandcassi.com/?p=2802</guid>
		<description><![CDATA[Drum roll, please! Dr. Caroline Hastings at Children&#8217;s Hospital Oakland and Research Center received a call on Friday afternoon from the U.S. Food and Drug Administration regarding the orphan drug submission we made at the end of February. While we have not received the official letter by mail (probably next week), it appears our Orphan [...]]]></description>
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		<slash:comments>4</slash:comments>
		</item>
		<item>
		<title>FDA Orphan Drug Workshop Makes Filing Applications Easy &#8211; Even For Rare Disease Patient Advocates!</title>
		<link>http://addiandcassi.com/fda-orphan-drug-workshop-makes-filing-applications-easy-even-for-rare-disease-patient-advocates/</link>
		<comments>http://addiandcassi.com/fda-orphan-drug-workshop-makes-filing-applications-easy-even-for-rare-disease-patient-advocates/#comments</comments>
		<pubDate>Sun, 28 Feb 2010 06:39:35 +0000</pubDate>
		<dc:creator>Chris Hempel</dc:creator>
				<category><![CDATA[Featured Stories]]></category>
		<category><![CDATA[Actelion]]></category>
		<category><![CDATA[Children’s Hospital of Oakland Research Institute]]></category>
		<category><![CDATA[Claremont]]></category>
		<category><![CDATA[FDA Orphan Drug Workshop]]></category>
		<category><![CDATA[Hydroxy Propel Beta Cyclodextrin]]></category>
		<category><![CDATA[Keck Graduate Institute’s Center for Rare Disease Therapies]]></category>
		<category><![CDATA[Niemann Pick Type C disease]]></category>
		<category><![CDATA[Orphan Drug Application Process]]></category>
		<category><![CDATA[U.S. Food and Drug Administration]]></category>
		<category><![CDATA[University of Minnesota]]></category>
		<category><![CDATA[World Rare Disease Day]]></category>
		<category><![CDATA[Zavesca]]></category>

		<guid isPermaLink="false">http://addiandcassi.com/?p=2570</guid>
		<description><![CDATA[At a historic orphan drug workshop held by the U.S. Food and Drug Administration Feb. 25-26 and before World Rare Disease Day 2010, we filed a momentous orphan drug application with the FDA for the treatment of Niemann Pick Type C disease with cyclodextrin. Our filing occurred in Claremont, CA, at the Keck Graduate Institute’s Center [...]]]></description>
		<wfw:commentRss>http://addiandcassi.com/fda-orphan-drug-workshop-makes-filing-applications-easy-even-for-rare-disease-patient-advocates/feed/</wfw:commentRss>
		<slash:comments>8</slash:comments>
		</item>
		<item>
		<title>The Road to Building a New Orphan Drug &#8211; Am I Mad?</title>
		<link>http://addiandcassi.com/the-road-to-building-a-new-orphan-drug-am-i-mad/</link>
		<comments>http://addiandcassi.com/the-road-to-building-a-new-orphan-drug-am-i-mad/#comments</comments>
		<pubDate>Fri, 05 Feb 2010 04:41:15 +0000</pubDate>
		<dc:creator>Chris Hempel</dc:creator>
				<category><![CDATA[Cyclodextrin]]></category>
		<category><![CDATA[Addi and Cassi Hempel]]></category>
		<category><![CDATA[Center for Rare Disease Therapies]]></category>
		<category><![CDATA[Children's Hospital Oakland Research Institute]]></category>
		<category><![CDATA[cholesterol drug]]></category>
		<category><![CDATA[FDA]]></category>
		<category><![CDATA[FDA Build an Orphan Drug Workshop]]></category>
		<category><![CDATA[Filing Orphan Drug Application]]></category>
		<category><![CDATA[Hydroxy Propel Beta Cyclodextrin]]></category>
		<category><![CDATA[identical twins]]></category>
		<category><![CDATA[Keck Graduate Institute]]></category>
		<category><![CDATA[Niemann Pick Type C]]></category>
		<category><![CDATA[rare disease]]></category>
		<category><![CDATA[sugar molecule]]></category>
		<category><![CDATA[World Rare Disease Day 2010]]></category>

		<guid isPermaLink="false">http://addiandcassi.com/wordpress/?p=2518</guid>
		<description><![CDATA[On February 25-26, 2010, I will be attending the inaugural FDA Build-an-Orphan-Drug-Workshop hosted by the Center for Rare Disease Therapies at Keck Graduate Institute (KGI) in Claremont, Calif.  FDA agency experts will be on hand to provide guidance on applying for orphan drug designation. I will be attending the workshop with Dr. Ron Browne, hired [...]]]></description>
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		<slash:comments>4</slash:comments>
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